#The markster mark mejis plus
Treatment A (n = 24 patients) received 1 symbiotic sachet Flortec(©) (Lactobacillus paracasei B21060) once daily plus high-fibre diet for 6 mo. Symptomatic uncomplicated diverticular disease patients were randomized to two treatment arms A or B. Consecutive outpatients with symptomatic uncomplicated diverticular disease, aged 40-80 years, evaluated in 4 Gastroenterology Units, were enrolled. This study was a multicentre, 6-mo randomized, controlled, parallel-group intervention with a preceding 4-wk washout period. To investigate in symptomatic uncomplicated diverticular disease the efficacy of symbiotics associated with a high-fibre diet on abdominal symptoms. Lahner, Edith Esposito, Gianluca Zullo, Angelo Hassan, Cesare Cannaviello, Claudio Paolo, Maria Carla Di Pallotta, Lorella Garbagna, Nicoletta Grossi, Enzo Annibale, Bruno High-fibre diet and Lactobacillus paracasei B21060 in symptomatic uncomplicated diverticular disease. Even if based on a small number of patients, the study demonstrates the absence of inflammation in the mucosa of subjects affected by uncomplicated diverticular disease. Mean values of mucosal cytokines and of the other tested parameters did not show statistically significant differences between patients with uncomplicated diverticular disease and controls. No histological differences were detected between the patients with an uncomplicated diverticular disease and controls. For statistical analysis Student's t test and Spearman correlation test were used. Histochemistry for transglutaminase type 2 and TUNEL were performed on the histological sections, in addition to morphologic evaluation, as markers of tissue remodelling and apoptosis. Specimens were homogenised and IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, IFN gamma, TNF alfa (searchlight multiplex technique), TGF beta, transglutaminase type 2 and caspase 9 were measured. Endoscopic biopsies of colon from 10 patients with symptomatic uncomplicated diverticular disease and 10 from subjects without diverticula (controls) were taken.
Our purpose was to evaluate the presence of inflammation in the colonic mucosa of patients with symptomatic uncomplicated diverticular disease compared with subjects without diverticula.
Nowadays, patients are often treated with antinflammatory drugs (5-aminosalicilic acid). Symptoms are aspecific and overlapping with those of irritable bowel syndrome. Uncomplicated diverticular disease is a common condition in patients older than 50Â years. Absence of mucosal inflammation in uncomplicated diverticular disease.Įlli, Luca Roncoroni, Leda Bardella, Maria Teresa Terrani, Claudia Bonura, Antonella Ciulla, Michele Marconi, Stefano Piodi, Luca
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